Greater Pharma Co., Ltd. is honored and proud to collaborate on the technology transfer of the probiotic strain Lactobacillus rhamnosus L34, or L34, a new Thai strain from the research team at the Faculty of Medicine, Chulalongkorn University. This research, which has been clinically validated and proven safe, will be further developed into probiotic products for the health of Thai people.

The starting point is the knowledge of Thai researchers.

Our goal is to improve the health of Thai people through a sustainable source of Thai probiotic strains. Currently, although many probiotic products are available on the market, our research team found that most of them use imported strains. Due to the unique lifestyle and dietary habits of Thai people, who consume a lot of spicy food, these imported strains are often destroyed in the stomach by the spiciness of chili peppers (capsaicin). Only a limited number survive to reach the intestines and provide benefits to the body. Therefore, many products using imported strains need to be developed using a large number and variety of Thai strains.

Furthermore, most products available on the market… While the focus is primarily on promoting gut health and claiming benefits linked to other bodily systems such as the gut-brain axis, gut-skin axis, and gut-immune axis, most research lacks concrete clinical support. Furthermore, there’s a lack of research linking the benefits of probiotics to non-communicable diseases (NCDs), a significant concern for the elderly in Thailand’s aging society.

Therefore, with dedicated research, Thai scientists from the Faculty of Medicine, Chulalongkorn University, discovered a new Thai strain, L34. This probiotic was subsequently studied, and the results showed that L34 is significantly effective in addressing leaky gut syndrome and reducing kidney fibrosis in mice induced with renal failure. It also reduced the leakage of uremic toxins in Thai patients. The study also showed statistically significant results in patients with chronic kidney disease (CKD) stages 3-5 who were not undergoing dialysis.

Greater Pharma’s Role: Connecting Research to Practical Application

As a leader in Thai health innovation with over 60 years of experience in quality pharmaceutical and health products, Greater Pharma Co., Ltd. has received technology transfer and applied research knowledge to develop production processes, resulting in high-quality products with a delicious (strawberry) taste, easy to consume, and manufactured in a PIC/S GMP-certified facility. Production is managed and controlled systematically and rigorously at every stage to maintain the quality of the L34 microbial strain, ensuring product efficacy, safety, and compliance with international quality requirements.

We believe that scientifically proven knowledge, coupled with collaboration between academia and industry, is the key to sustainable innovation. This collaboration marks another significant step in pushing Thai research into real products, using a Thai probiotic strain developed by Thai researchers for the health of Thai people.

Prometa L34 is now officially available.

Available at:

Leading pharmacies and medical supply stores nationwide.
Participating hospitals and clinics
Official online channel of Greater Pharma Co., Ltd.

For your convenience in finding pharmacies near you, you can check the list of participating pharmacies.

For more information, please contact:
Marketing Department, Greater Pharma Co., Ltd.
Tel: 02-886-8190-9
Website: www.greaterpharma.com

In recent years, the trend of focusing on internal health has steadily increased. One topic receiving particular attention is the gut microbiome and probiotics, which are beneficial bacteria that help balance the digestive system and the body’s immune system. However, this rapid popularity has also flooded the market with numerous probiotic products. Some products make exaggerated claims or lack clear supporting research, leaving consumers confused about which probiotics are truly effective and suitable for Thai people.

Therefore, Thai researchers have conducted a systematic study to find the connection between the gut, the immune system, and kidney health. They discovered that the gut is not just the digestive system, but the foundation of overall health, including the immune system, inflammation, and even kidney function.

How does a healthy gut affect the kidneys? A secret many don’t know.

Many may not realize that the gut and kidneys are more deeply interconnected than they think. Our intestines are home to trillions of microorganisms. When the gut system is healthy and the microorganisms are in balance, the body digests food efficiently, produces beneficial substances, and reduces overall inflammation. However, when the microorganisms are imbalanced, or when a condition called leaky gut occurs, the intestinal wall weakens, allowing toxins, such as those from food, to enter.

Bacterial toxins
Toxins from waste products, known as uremic toxins,

can easily leak into the bloodstream. When these substances enter the body in excessive amounts, they cause inflammation throughout the body, forcing the kidneys to work harder to eliminate waste and potentially leading to long-term kidney damage.

What are probiotics and why are they important for the body?

Probiotics are “good bacteria” that are beneficial to the body, especially the digestive system. They have important functions such as:

Aiding digestion
Reducing certain toxins in the intestines
Balancing gut microbiota
Boosting immunity
Reducing inflammation
Strengthening the intestinal lining

However, not all probiotics are the same. The benefits of probiotics depend on their specific strain, meaning each probiotic will have a significantly different effect on the body.

“L34” – A Thai probiotic strain, researched by Thais for Thais.

One of the most prominent probiotics currently is Lactobacillus rhamnosus L34, or L34 for short. This strain was discovered for the first time in the world from the intestines of Thai people by Thai researchers and has been published in an international journal. This discovery is considered a breakthrough for Thai medicine and science because L34 is a strain well-suited to the gut conditions and eating habits of Thai people, such as their consumption of spicy, fatty, and salty foods, which can easily damage the intestinal lining compared to some other nationalities.

Key Features of Probiotic L34:

✔ Acid and Bile Resistant, Reaches the Intestines Effectively
L34 passes through the stomach very well, traveling to the small and large intestines alive.

✔ Excellent Adhesion to the Intestinal Lining
Helps build a protective barrier in the intestinal wall, increasing strength and reducing leaky gut syndrome.

✔ Reduces Inflammatory Toxins
Helps reduce toxins that cause inflammation, which is associated with kidney disease, allergies, and the immune system.

✔ Suitable for Thai Diet
Studies have shown that L34 can withstand changes in the digestive environment of Thai people.

✔ Supported by Human Research in Thai People
It is one of the few probiotics backed by research in the “real Thai population,” providing greater assurance.

L34 Research in Animal Models: Helps Slow Kidney Deterioration

One study, conducted on mice induced with kidney failure, found that continuous administration of L34 for 10–14 weeks resulted in:

Renal fibrosis decreased;
Systemic inflammation decreased;
The kidneys were able to eliminate waste more efficiently.

These results clearly indicate that reducing toxins and inflammation in the gut can effectively lessen the burden on the kidneys.

L34 research in Thai humans: Clearly positive results.

In patients with early-stage chronic kidney disease (not yet undergoing dialysis) who consumed L34 continuously for one month, the following was observed:

Reduced inflammatory substances;
Improved bowel function;
Increased beneficial microorganisms;
Decreased pathogenic microorganisms;
Reduced uremic toxins.

This indicates that L34 has positive effects on the gut system, immunity, and reduces the risk of future kidney failure.

Prometa L34: A Thai probiotic product from a joint research project between Chulalongkorn University and Greater Pharma.

From intensive research, the product GREATER Prometa L34 was developed by researchers from the Faculty of Medicine. Developed by Chulalongkorn University and manufactured by Greater Pharma, Thailand’s leading health innovation company for over 60 years.

Key Features of Prometa L34:

Uses the L34 probiotic strain, supported by research in Thai people.
Produced under GMP standards.
Approved by the Thai FDA.
Good taste, easy to consume, no mixing required.
Supports gut health, immunity, and kidney health in the long term.
If your gut is healthy, your overall health will improve.

The specific L34 probiotic strain, supported by research in both animals and humans, is a suitable option for Thai people. It helps support the gut system, reduce toxins, reduce inflammation, and reduce risk factors that put extra strain on the kidneys.

Prometa L34 is therefore a probiotic that truly meets the needs of Thai people who want to take care of their health from the inside out.